PAIN MANAGEMENT RESEARCH

AND CLINICAL TRIALS

The National Pain Institute is leading the way to establish national standards regarding pain management.

Research supports the interdisciplinary approach as the best way to treat pain. The National Pain Research Institute is dedicated to the advancement of new and improved medications to aide in the treatment of the chronic pain patient. Check back periodically for any new clinical trials.

YOU MUST MEET CERTAIN CRITERIA TO BE CONSIDERED FOR ENROLLMENT INTO OUR OPEN CLINICAL RESEARCH TRIALS.

There is no cost to you for your participation. Some trials offer compensation for time and travel. You don’t have to be an NPI patient to be a part of our clinical research trials. You can also enroll if you are a patient at any NPI location and can travel to our Winter Park Office.

To see if you would qualify for one of our trials, please ask to see the research nurse or call 407-203-7936 or 866-951-PAIN (7246). You can also ask your NPI physician for more information.

Download Our Clinical Research Trial Brochure

Center Overview

The National Pain Research Institute, LLC, is a division of the National Pain Institute, a Prospira PainCare Center of Excellence. Our research department, is currently conducting clinical trials in our Winter Park and Orlando offices. We have an established research program, with Investigators, clinical research coordinators and a research pharmacist. Our unique interdisciplinary treatment approach has been determined to be the most effective methodology according to the American Academy of Pain Management. We specialize in conducting clinical trials involving all areas of the chronic pain syndrome.

Mission Statement

"The National Pain Research Institute is a clinical research investigative site dedicated to providing our patients with qualified professionals who utilize good clinical practices to ensure the patient’s safety and wellbeing. Through clinical trials, our patients are offered access to new medical treatments and devices. We pride ourselves on providing quality data to our study sponsors, which is crucial in maintaining the safety and efficacy of the trials in which we participate. It is our duty to the people we serve in our community to provide the highest ethical standard of care and the opportunity to improve their quality of life through clinical trials."

Patient Demographics

Chronic pain diseases include all age groups, Our patient population is primarily between the ages of 40 to 75, however we treat patients from the age of 18 and up. Pain management is a very comprehensive specialty. Our patients have many different pain related diagnosis and issues they are being treated for. We manage the pain care for not only patients with age related disease but also for patients with traumatic injury as well. Our chronic pain patient database consists of over 100,000 patients and we treat patients from all across the state of Florida.

Meet our Team of Investigators

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CHERIAN K. SAJAN, M.D., PI/SUB INVESTIGATOR

Dr. Sajan has been with National Pain Institute since 2011. He completed a pain fellowship with us and went on to become an attending physician, principal investigator and sub-investigator. Dr Sajan is now the medical director of National Pain Institute Florida. Dr. Sajan is Board Certified in Physical Medicine and Rehabilitation and Pain Management.

He is NIH trained for Human Research Subject protection and is GCP trained before every new trial. Dr. Sajan is committed to the research department and is actively involved in study feasibility, recruitment and assessment of our research patients.


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ANTHONY F. AFONG, M.D., PRINCIPAL INVESTIGATOR, M.D., PRINCIPAL INVESTIGATOR

Dr. Afong has been with National Pain Institute since 2006. He started with us as a fellow as well and went on to become medical director and principal investigator of our Port St Lucie, Fl, office.

Dr. Afong is NIH and GCP trained and has conducted trials in Chronic Low Back Pain, Opioid Induced Constipation and Intrathecal Hydromorphone for Chronic Pain.

He is instrumental in the study feasibility and recruitment aspects of pretrial selection for his site.


Cesar A. Lassalle, MD

CESAR A. LASSALLE-NIEVES, M.D., PRINCIPAL INVESTIGATOR

Dr. Lassalle has been with the National Pain Research Institute since 2012. After completing a pain fellowship in our pain management practice and serving as a subinvestigator on our clinical trials, he became Medical Director for the Advanced Interventional Pain Clinic and a Principal Investigator for the National Pain Research Institute, Orlando office.

Dr. Lassalle is GCP certified through Clinical Trials Network NIDA and NIH for human research subject protection training. His patient database is strong and Dr. Lassalle is active in patient prescreening as well as study start up and conduct.

Research Team

MATTY CULBRETH- NOTARO, RN, BSN, CCRC- EXECUTIVE DIRECTOR OF RESEARCH ADMINISTRATION.

Matty is the Executive Director of Research Administration for Prospira Pain Care and the National Pain Research Institute, LLC (NPRI) corporation.

Matty received her Bachelor’s Degree in Nursing from the Florida State University in 1991 and began her nursing career in the Pediatric Intensive Care Unit at Miami Children’s Hospital. Her career in clinical research began at Nemours Children Clinic where she successfully developed and managed the research programs for the Orlando, and Pensacola, Fl. divisions and assisted with the ongoing development of the research programs for Arnold Palmer Children’s Hospital, and Orlando Regional Medical Center. In 2006, Matty established a Biomedical Research company called Global Clinical Research Management, Inc. As owner and President of GCRM, Inc. she was the key leader in developing the operational programs for the organization servicing thousands of clients across the country to include leading pharmaceutical companies, CRO’s , hospitals and private physician practices. Matty’s focus was to assist physician practices and hospitals throughout the country in implementing or further developing the clinical research programs within their institution. The physicians and their patients were given access to cutting edge medicine, providing them with leading care. Her expertise in the area of clinical research brought her across the country to Southern California where she worked as a consultant for MemorialCare Health System. She joined forces with a team of experts to revamp and restructure the Biomedical Research Program, enterprise wide concentrating her efforts in Clinical Operations as the Director for that division. She managed the clinical operations for Long Beach Memorial, Millers Women and Children Hospital, Saddleback Memorial and Orange Coast Memorial.

Matty is a seasoned veteran with well over twenty five years of experience supervising protocol teams for a variety of corporate entities. She comes to Propsira and NPRI, LLC with a wealth of knowledge and experience in the area of clinical operations and has successfully managed a variety of Clinical Research projects to include: Phases I-IV, Investigator Initiated Trials, External Non-Clinical Research Studies, Observational and Registry trials.

Her scope of management capabilities include working directly with various globalized talent ranging from Vice Presidents, Medical Directors, Investigators, Medical Liaisons, Global Study Coordinators, Affiliates, Jr/Sr Clinical Research Nurses Coordinators, Jr/Sr Clinical Research Associates, various Joint Committee Members, Legal and Patent Departments.

She is expertly trained in regulatory, budget, contract negotiation, quality assurance, compliance and clinical research operations.


PATRICIA MARTINEZ, MA, CLINICAL RESEARCH COORDINATOR

Patricia has been with National Pain Institute since 2005. She is the full time lead Clinical Research Coordinator our Winter Park, FL and Orlando office. Patricia is well trained in Good Clinical Practice Guidelines and is an expert in the coordination of clinical research trials. She is well versed in EKG functions, phlebotomy, Electronic Data Capture Systems, eDiary, UDS, site tablets and IATA certification for shipping dangerous goods. She completes monitoring visits, Site Initiation, close out visits, source creation and total conduction of each protocol. Patricia is a knowledgeable and reliable clinical research coordinator that maintains a high quality of work sought after by our sponsors. She also takes part in the training of our newer coordinators and the in servicing of our physicians on new protocols.

Other Information

The National Pain Research Institute, LLC, is able to use a central IRB. We have experience with many of the central IRBs: WIRB, Quorum, Schulman, NEIRB, Coast IRB, Aspire IRB, Copernicus and others. NPRI, LLC is a Clinical Research Coordinator Training facility. Our research structure involves the use of a CTMS to assist in the organization of our research trials and subjects.

Facility Description

Our interdisciplinary site offers multi-therapeutic outpatient care to our patients. Our patients are seen by Board Certified MDs and have the opportunity to have their entire treatment plan carried out in our office.

Our facility has X-ray capabilities as well as ECGs, and phlebotomy. We have infusion therapy for subjects requiring it. In our surgical procedure room we perform cervical and lumbar epidurals, cervical and lumbar Facet injections, flouroscopic guided Radio Frequency Lesioning, nerve blocks, trigger point injections, implantable medication dispensing pump trials, spinal cord stimulation trials and joint injections.

Our Winter Park office is just outside the city of Orlando. We are the largest pain management facility in the Central Florida area. We have direct access to the public transportation system with bus stops right outside our door.

Our Port St. Lucie facility is located directly off of I-95, in the heart of St. Lucie West. It also has easy access to the public transportation system.

Our Semoran location is just north of the Orlando International Airport, with ease of access by automobile, taxi or city transportation.

All of our facilities are easily accessible, with abundant parking.